Evidence Based Medicine

Searchable best evidence database, plus tailored email alert service, from the British Medical Journal and McMaster University. Free subscription required.

The Washington University Emergency Medicine Journal Club podcast provides an excellent way to keep up with the medical literature, improve patient care, and increase understanding of evidence-based medicine.

Organization promoting evidence-based decision making in perioperative medicine in order to improve the outcome of patients undergoing surgery.

Evidence-based clinical practice guidelines (as PDFs) in critical care.

Comprehensive, literature-based review of the epidemiology, genetic factors, clinical diagnosis, treatments, and pharmacology for psoriasis. [2013]

Practical lessons on the highly variable quality of systematic reviews themselves, with an illustrative case study showing how different systematic reviews on the same question can arrive at opposite conclusions. [2001]

Provides criteria to use to critically appraise systematic reviews and meta-analyses, and documents some of the key pitfalls of each. [2003]

Collection of fulltext copies of talks about evidence-based medicine.

Reviews multiple alternative systems for rating the quality of evidence and the strength of recommendations.

Teaching tips on using likelihood ratios. From the Evidence-Based Medicine Teaching Tips Working Group.

Describes I-SPY, a groundbreaking dynamic adaptive randomization model for accelerating both identification and regulatory approval of effective investigational agents. [2013]

Demonstrates how observational studies may provide moderate- to (rarely) high-strength evidence in systematic reviews. [2014]

An introduction to and rationale for meta-analysis, including presentation, interpretation, and biases. [2010]

Details the basic steps of evidence-based practice and provides signposts to more detailed information and assistance. Compiled by the Evidence-Based Practice Group South East and the Health Service Executive of Ireland. [2014]

Standard definitions for efficacy end points and events in early-stage adjuvant breast cancer clinical trials, from Memorial Sloan Kettering. [2007]

Explores the historic use of different endpoints, and the associated degree of regulatory flexibility shown, by the FDA to support regular and accelerated approval of cancer drugs. [2013]

An overview of the design, analysis, and interpretation of Mendelian randomization studies, with a special emphasis on assumptions and limitations, and an examination of different analytic strategies for strengthening causal inference. [2016]

Educational resource of the New York Academy of Medicine for evidence-based emergency medicine research; user's guide, journal club bank (member-only), and downloadable slides.

Introduction to and resources for evidence-based geriatrics, including sample scenarios and CATS. From the Center for Evidence-Based Medicine (CEBM).

Topic-categorized guidelines on specific diagnostic and treatment modalities in the diagnosis and management of patients, aggregated (but not develloped) by the National Center for Complementary and Integrative Health (NCCIH).

Bi-monthly publication for primary care and internal medicine practitioners, with contents of current issue, and searchable archives.

A multidisciplinary open access peer-reviewed journal that publishes basic and clinical research concerning all aspects of evidence based medicine.

Evidence-based review of the landmark studies on the treatment and management of patients with life-threatening neurological illnesses, postoperative neurosurgical complications, and neurological manifestations of systemic disease. [2014]

Evidence-based critical appraisal topic (CAT) repository covering the clinical neurosciences.

A systematic review based on the Institute of Medicine’s guideline development process to identify randomized controlled trials on the efficacy of integrative therapies for supportive care in patients receiving breast cancer treatment. [2014]

Evidence-based review from MD Anderson Cancer Center of mind-body techniques such as meditation, yoga, tai chi, and qigong for improvements in different aspects of the quality of life of cancer patients. [2015]