Education

Practical lessons on the highly variable quality of systematic reviews themselves, with an illustrative case study showing how different systematic reviews on the same question can arrive at opposite conclusions. [2001]

Provides criteria to use to critically appraise systematic reviews and meta-analyses, and documents some of the key pitfalls of each. [2003]

Collection of fulltext copies of talks about evidence-based medicine.

Reviews multiple alternative systems for rating the quality of evidence and the strength of recommendations.

Teaching tips on using likelihood ratios. From the Evidence-Based Medicine Teaching Tips Working Group.

Describes I-SPY, a groundbreaking dynamic adaptive randomization model for accelerating both identification and regulatory approval of effective investigational agents. [2013]

Demonstrates how observational studies may provide moderate- to (rarely) high-strength evidence in systematic reviews. [2014]

An introduction to and rationale for meta-analysis, including presentation, interpretation, and biases. [2010]

Details the basic steps of evidence-based practice and provides signposts to more detailed information and assistance. Compiled by the Evidence-Based Practice Group South East and the Health Service Executive of Ireland. [2014]

Standard definitions for efficacy end points and events in early-stage adjuvant breast cancer clinical trials, from Memorial Sloan Kettering. [2007]

Explores the historic use of different endpoints, and the associated degree of regulatory flexibility shown, by the FDA to support regular and accelerated approval of cancer drugs. [2013]

An overview of the design, analysis, and interpretation of Mendelian randomization studies, with a special emphasis on assumptions and limitations, and an examination of different analytic strategies for strengthening causal inference. [2016]